Article
Lack of BRAF(V600E) mutations in giant congenital melanocytic nevi in a Chinese population.
The American Journal of dermatopathology - 1 Jun 2011
Wu Di, Wang Mei, Wang Xingang, Yin Ningbei, Song Tao, Li Haidong, Yu Jun, Wang Duen-Mei, Zhao Zhenmin
Abstract excerpt
Giant congenital melanocytic nevi (CMNs) are at an increased risk for malignant transformation. To explore the mutation frequencies of BRAF(V600E) (V-raf murine sarcoma virus oncogene homolog B1) and NRAS (neuroblastoma ras viral oncogene homolog) codon 61 in CMNs of Chinese, we selected 55 paraffin-embedded tissue blocks, including 37 cases of medium CMNs (1.5-20cm) and 18 cases of giant CMNs (>20 cm). Direct...
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