Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.

doi:10.1038/jid.2015.114

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Article

Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.

The Journal of investigative dermatology - 1 Aug 2015

Pawlikowski Jeffrey S, Brock Claire, Chen Sheau-Chiann, Al-Olabi Lara, Nixon Colin, McGregor Fiona, Paine Simon, Chanudet Estelle, Lambie Wendy, Holmes William M, Mullin James M, Richmond Ann, Wu Hong, Blyth Karen, King Ayala, Kinsler Veronica A, Adams Peter D

Abstract excerpt

Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain, or leptomeninges. We have previously proposed a key role for Wnt...

Topics

Animals
Child
DNA
Disease Models, Animal
Female
Humans
MAP Kinase Kinase Kinases
Male
Membrane Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Monomeric GTP-Binding Proteins

Mutation

Nevus, Pigmented

Sequence Analysis, DNA

Signal Transduction

Skin Neoplasms

Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25815427
DOI: 10.1038/jid.2015.114
PMCID: PMC4539947

Genes

NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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