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Article

Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion.

Developmental biology - 15 May 2019

McConnell Alicia M, Mito Jeffrey K, Ablain Julien, Dang Michelle, Formichella Luke, Fisher David E, Zon Leonard I

Abstract excerpt

NRAS mutations are frequently found in many deadly malignancies and are the second most common oncogene driving malignant melanoma. Here, we generate a rapid transient transgenic zebrafish model of NRASQ61R-mutant melanoma. These fish develop extensive melanocytic proliferation in approximately 4 weeks. The majority of these lesions do not engraft upon transplantation and lack overt histologic features of...

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Identifiers

PMID: 29883661
DOI: 10.1016/j.ydbio.2018.05.026
PMCID: PMC6281797

Genes

NRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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