Article
NRAS mutation is the sole recurrent somatic mutation in large congenital melanocytic nevi.
The Journal of investigative dermatology - 1 Apr 2014
Charbel Christelle, Fontaine Romain H, Malouf Gabriel G, Picard Arnaud, Kadlub Natacha, El-Murr Nizar, How-Kit Alexandre, Su Xiaoping, Coulomb-L'Hermine Aurore, Tost Jorg, Mourah Samia, Aractingi Selim, Guégan Sarah
Abstract excerpt
Congenital melanocytic nevus (CMN) is a particular melanocytic in utero proliferation characterized by an increased risk of melanoma transformation during infancy or adulthood. NRAS and BRAF mutations have consistently been reported in CMN samples, but until recently results have been contradictory. We therefore studied a series of large and giant CMNs and compared them with small and medium CMNs using Sanger...
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