Acquisition of Somatic NRAS Mutations in Central Nervous System Melanocytes: A Predisposing Risk Factor to Primary Melanoma of the Central Nervous System, a Frequently Forgotten Pitfall in Congenital Nevi.

Abstract excerpt

Congenital melanocytic nevi (CMN) are benign melanocytic proliferations that are usually present at birth. A somatic mosaicism for an NRAS point mutation is responsible for the several phenotypic abnormalities that may be associated with congenital nevi. We report the case of a 7-year-old boy with a proliferative nodule (PN) arising in a Giant CMN completely excised and with several visceral and intraspinal...

Topics

• Child
• GTP Phosphohydrolases
• Humans
• Male
• Melanoma
• Membrane Proteins
• Mutation
• Neoplasm Metastasis
• Nevus, Pigmented
• Skin Neoplasms