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Acquired WT1 mutations contribute to relapse of NPM1-mutated acute myeloid leukemia following allogeneic hematopoietic stem cell transplant.

Bone marrow transplantation - 1 Mar 2022

El Hussein Siba, DiNardo Courtney D, Takahashi Koichi, Khoury Joseph D, Fang Hong, Furudate Ken, Lyapichev Kirill A, Garces Sofia, Kanagal-Shamanna Rashmi, Ok Chi Young, Patel Keyur P, Routbort Mark J, Ravandi Farhad, Medeiros L Jeffrey, Wang Sa A, Loghavi Sanam

Abstract excerpt

The role of WT1 protein in hematopoiesis and leukemogenesisis incompletely elucidated. WT1 overexpression is common in acute myeloid leukemia (AML); however, WT1 mutations occur in only about 10% of cases, with increasing incidence in the setting of relapse. In this study, we investigated the clinical and molecular characteristics of WT1 mutations in NPM1-mutated AML, to enhance our understanding of the biology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34992253
DOI: 10.1038/s41409-021-01538-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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