Article
WT1 mutation in 470 adult patients with acute myeloid leukemia: stability during disease evolution and implication of its incorporation into a survival scoring system.
Blood - 24 Jun 2010
Hou Hsin-An, Huang Tai-Chung, Lin Liang-In, Liu Chieh-Yu, Chen Chien-Yuan, Chou Wen-Chien, Tang Jih-Luh, Tseng Mei-Hsuan, Huang Chi-Fei, Chiang Ying-Chieh, Lee Fen-Yu, Liu Ming-Chih, Yao Ming, Huang Shang-Yi, Ko Bor-Sheng, Hsu Szu-Chun, Wu Shang-Ju, Tsay Woei, Chen Yao-Chang, Tien Hwei-Fang
Abstract excerpt
The impact of WT1 mutations in acute myeloid leukemia (AML) is not completely settled. We aimed to determine the clinical implication of WT1 mutation in 470 de novo non-M3 AML patients and its stability during the clinical course. WT1 mutations were identified in 6.8% of total patients and 8.3% of younger patients with normal karyotype (CN-AML). The WT1 mutation was closely associated with younger age (P < .001),...
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