Impact of Wilms' tumor 1 gene (WT1) mutation on outcome of allogeneic hematopoietic-cell transplantation for acute myeloid leukemia: a retrospective multicenter cohort study from the ALWP/EBMT registry.

doi:10.1038/s41409-025-02727-7

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Article

Impact of Wilms' tumor 1 gene (WT1) mutation on outcome of allogeneic hematopoietic-cell transplantation for acute myeloid leukemia: a retrospective multicenter cohort study from the ALWP/EBMT registry.

Bone marrow transplantation - 1 Jan 2026

Nagler Arnon, Esteve Jordi, Galimard Jacques-Emmanuel, Sanz Jaime, Poire Xavier, Collin Matthew, Maertens Johan, Huang He, Itäla-Remes Maija, Halahleh Khalid, Pascual Cascon Maria Jesús, Chiusolo Patrizia, Griskevicius Laimonas, Kaare Ain, De Becker Ann, Jindra Pavel, Pérez-Simón Jose Antonio, Bazarbachi Ali, Brissot Eolia, Ciceri Fabio, Mohty Mohamad

Abstract excerpt

We compared transplantation outcomes of AML patients with WT1 mutation (mWT1), identified by next-generation sequencing, to those of patients with wild-type WT1 AML (wtWT1). 703 patients were included, 50 with mWT1 and 653 with wtWT1. Patients with mWT1 were younger (median age: 45.6 vs. 56.4 years, p < 0.001), with a higher proportion of females (66% vs. 47.6%, p = 0.01), higher frequency of mutations in...

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PMID: 41102401
DOI: 10.1038/s41409-025-02727-7
PMCID: PMC12819150

Genes

WT1
CR1
FLT3
NRM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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