Article

A deep learning model embedded framework to distinguish DNA and RNA mutations directly from RNA-seq

2023-10-20

Abstract excerpt

We develop a stepwise computational framework, called DEMINING, to directly d etect e xpressed DNA and RNA m utations in R N A deep sequenc ing data. DEMINING incorporates a deep learning model named DeepDDR, which facilitates the separation of expressed DNA mutations from RNA mutations after RNA-seq read mapping and pileup. When applied in RNA-seq of acute myeloid leukemia patients, DEMINING uncovered previo...

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Literature Corpus work: 60ae6fb3-e22f-5a31-bc08-9a35bc007ea7
DOI: 10.1101/2023.10.17.562625

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