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Article

Unsupervised detection of fragment length signatures of circulating tumor DNA using non-negative matrix factorization.

eLife - 27 Jul 2022

Renaud Gabriel, Nørgaard Maibritt, Lindberg Johan, Grönberg Henrik, De Laere Bram, Jensen Jørgen Bjerggaard, Borre Michael, Andersen Claus Lindbjerg, Sørensen Karina Dalsgaard, Maretty Lasse, Besenbacher Søren

Abstract excerpt

Sequencing of cell-free DNA (cfDNA) is currently being used to detect cancer by searching both for mutational and non-mutational alterations. Recent work has shown that the length distribution of cfDNA fragments from a cancer patient can inform tumor load and type. Here, we propose non-negative matrix factorization (NMF) of fragment length distributions as a novel and completely unsupervised method for studying...

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Identifiers

PMID: 35894300
DOI: 10.7554/eLife.71569
PMCID: PMC9363120

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