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The Impact of the hAPP695 SW Transgene and Associated Amyloid-β Accumulation on Murine Hippocampal Biochemical Pathways

22 Dec 2021

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) peptide in the brain. OBJECTIVE: To gain a better insight into alterations in major biochemical pathways underlying AD. METHODS: We compared metabolomic profiles of hippocampal tissue of 20-month-old female Tg2576 mice expressing the familial AD-associated hAPP695SW transgene with their...

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PMID: 34958022
DOI: 10.3233/jad-215084

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