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Article

Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease.

Current Alzheimer research - 1 May 2013

Cuadrado-Tejedor Mar, Cabodevilla Jesús Felipe, Zamarbide Marta, Gómez-Isla Teresa, Franco Rafael, Perez-Mediavilla Alberto

Abstract excerpt

The Tg2576 mouse, which carries the Swedish mutant form of human β-amyloid precursor protein (hAPP(swe)), develops Alzheimer's Disease (AD)-like phenotype (synaptic pathology, cognitive impairment and β amyloid -Aβ- plaques.) in the absence of significant neuronal loss. We have analyzed the hippocampal proteome of Tg2576, focusing on changes at 7 months of age, when Aβ levels begin to increase but cognitive...

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Identifiers

PMID: 23545067
DOI: 10.2174/1567205011310040005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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