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Article

Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Hinteregger Barbara, Loeffler Tina, Flunkert Stefanie, Neddens Joerg, Bayer Thomas A, Madl Tobias, Hutter-Paier Birgit

Abstract excerpt

BACKGROUND: Preclinical Alzheimer's disease (AD) research strongly depends on transgenic mouse models that display major symptoms of the disease. Although several AD mouse models have been developed representing relevant pathologies, only a fraction of available mouse models, like the Tg4-42 mouse model, display hippocampal atrophy caused by the death of neurons as the key feature of AD. The Tg4-42 mouse model is...

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Identifiers

PMID: 33646155
DOI: 10.3233/JAD-201204
PMCID: PMC8150512

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