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Article

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

11 Nov 2015

Abstract excerpt

Because age is the greatest risk factor for sporadic Alzheimer's disease (AD), phenotypic screens based upon old age-associated brain toxicities were used to develop the potent neurotrophic drug J147. Since certain aspects of aging may be primary cause of AD, we hypothesized that J147 would be effective against AD-associated pathology in rapidly aging SAMP8 mice and could be used to identify some of the molecular...

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PMID: 26564964
DOI: 10.18632/aging.100838

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