Article
Next-generation biomarker discovery in Alzheimer's disease using metabolomics - from animal to human studies.
Bioanalysis - 1 Sept 2018
Hurtado Marina Ollé, Kohler Isabelle, de Lange Elizabeth Cm
Abstract excerpt
Alzheimer's disease (AD) is a complex disease driven mainly by neuronal loss due to accumulation of intracellular neurofibrillary tangles and amyloid β aggregates in the brain. The diagnosis of AD currently relies on clinical symptoms while the disease can only be confirmed at autopsy. The few available biomarkers allowing for diagnosis are typically detected many years after the onset of the disease. New...
Topics
- Alzheimer Disease
- Animals
- Biomarkers
- Humans
- Metabolomics
- Mutation
- Proteomics