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Article

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease.

Lipids in health and disease - 9 May 2013

Tajima Yoko, Ishikawa Masaki, Maekawa Keiko, Murayama Mayumi, Senoo Yuya, Nishimaki-Mogami Tomoko, Nakanishi Hiroki, Ikeda Kazutaka, Arita Makoto, Taguchi Ryo, Okuno Alato, Mikawa Ryuta, Niida Shumpei, Takikawa Osamu, Saito Yoshiro

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD), the most common cause of dementia among neurodegenerative diseases, afflicts millions of elderly people worldwide. In addition to amyloid-beta (Aβ) peptide and phosphorylated tau, lipid dysregulation is suggested to participate in AD pathogenesis. However, alterations in individual lipid species and their role in AD disease progression remain unclear. METHODS: We performed a...

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Identifiers

PMID: 23659495
DOI: 10.1186/1476-511X-12-68
PMCID: PMC3668217

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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