Article

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue

2025-11-06

Abstract excerpt

Metabolic dysregulation is a hallmark of Alzheimer’s disease (AD), with numerous studies characterizing metabolic pathways associated with AD onset and progression. A significant limitation of these studies has been a predominant focus on non-Hispanic white participants. Despite evidence that AD prevalence, progression, and biomarkers differ across ethnoracial groups, it remains unclear whether previously identifi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4ac76df9-b004-5865-8daf-6f59d9b847be
DOI: 10.1101/2025.11.04.25339489

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissueDOI 10.1101/2025.11.04.25339489Read

Differences in Plasma Metabolites Related to Alzheimer’s Disease, APOE-ε4 status and EthnicitySemantic proximity Read

A seven-year longitudinal study of the Alzheimer’s disease blood metabolomeSemantic proximity Read

Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer disease brainsSemantic proximity Read

Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.Semantic proximity Read

Multi-Omic Analyses Characterize the Ceramide/Sphingomyelin Pathway as a Therapeutic Target in Alzheimer’s DiseaseSemantic proximity Read

Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohortSemantic proximity Read

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.Semantic proximity Read

Sex Differences in the Metabolome of Alzheimer's Disease ProgressionSemantic proximity Read

Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer's risk factors among 1,111 cohort participantsSemantic proximity Read

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer’s Disease and Older Controls in Multi-Ethnic PopulationsSemantic proximity Read

Cell type-specific master metabolic regulators of Alzheimer’s diseaseSemantic proximity Read

Lipidomic alterations in the cerebral cortex and white matter in sporadic Alzheimer’s diseaseSemantic proximity Read