Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinoma

21 Dec 2021

Abstract excerpt

Colorectal Cancer (CRC) with Microsatellite instability (MSI) and mutLhomolog-1 (MLH1) gene deficiency are less aggressive than MLH1 proficient cancers. MLH1 is involved in several cellular processes, but its connection with the autophagy-dependent cellular response towards anticancer drugs remains unclear. In this study, we aimed to investigate the interaction between MLH1 and the autophagy marker LC3, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to CRISPR and Genetic Engineering
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34952246
DOI: 10.1016/j.neo.2021.12.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinomaPMID 34952246Read ↗

MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell deathSemantic proximity Read ↗

MSH3 Mediates Sensitization of Colorectal Cancer Cells to Cisplatin, Oxaliplatin, and a Poly(ADP-ribose) Polymerase InhibitorSemantic proximity Read ↗

Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathwaysSemantic proximity Read ↗

MSH3 Mismatch Repair Protein Regulates Sensitivity to Cytotoxic Drugs and a Histone Deacetylase Inhibitor in Human Colon Carcinoma CellsSemantic proximity Read ↗

Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.Semantic proximity Read ↗

Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR‐D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancerSemantic proximity Read ↗

Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 miceSemantic proximity Read ↗

MLH1 deficiency leads to deregulated mitochondrial metabolism.Semantic proximity Read ↗

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT SignalingSemantic proximity Read ↗

Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.Semantic proximity Read ↗

Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.Semantic proximity Read ↗

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.