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MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death

13 Oct 2014

Abstract excerpt

p53-regulated caspase-independent cell death has been implicated in suppression of tumorigenesis, however, the regulating mechanisms are poorly understood. We previously reported that 8-oxoguanine (8-oxoG) accumulation in nuclear DNA (nDNA) and mitochondrial DNA triggers two distinct caspase-independent cell death through buildup of single-strand DNA breaks by MutY homolog (MUTYH), an adenine DNA glycosylase. One...

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PMID: 25310643
DOI: 10.1038/oncsis.2014.35

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