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Article

Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR‐D)/microsatellite instability (MSI) via interacting with Mis18α in colorectal cancer

1 Mar 2021

Abstract excerpt

Background and Purpose It is well known that microsatellite instability‐high (MSI‐H) is associated with 5‐fluorouracil (5‐FU) resistance in colorectal cancer. MSI‐H is the phenotype of DNA mismatch repair deficiency (MMR‐D), mainly occurring due to hypermethylation of MLH1 promoter CpG island. However, the mechanisms of MMR‐D/MSI‐H are unclear. We aim to investigate the pathway of MMR‐D/MSI‐H involved in 5‐FU...

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PMID: 33645631
DOI: 10.1111/bph.15422

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