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Article

Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs

9 Feb 2015

Abstract excerpt

Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries. Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis. Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in a critical subpopulation of CRC cells, underscores the importance of elucidating LRH-1's role in this disease....

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PMID: 25675535
DOI: 10.1073/pnas.1500978112

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