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Tissue-specific reduction in MLH1 expression induces microsatellite instability in intestine of Mlh1 mice

9 Jul 2021

Abstract excerpt

Tumors of Lynch syndrome (LS) patients display high levels of microsatellite instability (MSI), which results from complete loss of DNA mismatch repair (MMR), in line with Knudson’s two-hit hypothesis. Why some organs, in particular those of the gastrointestinal (GI) tract, are prone to tumorigenesis in LS remains unknown. We hypothesized that MMR is haploinsufficient in certain tissues, compromising...

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PMID: 34311271
DOI: 10.1016/j.dnarep.2021.103178

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