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Downregulation of GLYR1 contributes to microsatellite instability colorectal cancer by targeting p21 via the p38MAPK and PI3K/AKT pathways

5 May 2020

Abstract excerpt

BACKGROUND: GLYR1 has a high mutation frequency in microsatellite instability colorectal cancer (MSI CRC) and is presumed to be a novel tumor suppressor. However, the role of GLYR1 in tumors has never been studied. In particular, the downregulation of GLYR1 in MSI CRC is worthy of further investigation. METHODS: Western blot and immunohistochemistry analyses were used to detect GLYR1 protein expression in CRC...

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PMID: 32370786
DOI: 10.1186/s13046-020-01578-y

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