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Article

MLH1 deficiency leads to deregulated mitochondrial metabolism.

Cell death & disease - 22 Oct 2019

Rashid Sukaina, Freitas Marta O, Cucchi Danilo, Bridge Gemma, Yao Zhi, Gay Laura, Williams Marc, Wang Jun, Suraweera Nirosha, Silver Andrew, McDonald Stuart A C, Chelala Claude, Szabadkai Gyorgy, Martin Sarah A

Abstract excerpt

The DNA mismatch repair (MMR) pathway is responsible for the repair of base-base mismatches and insertion/deletion loops that arise during DNA replication. MMR deficiency is currently estimated to be present in 15-17% of colorectal cancer cases and 30% of endometrial cancers. MLH1 is one of the key proteins involved in the MMR pathway. Inhibition of a number of mitochondrial genes, including POLG and PINK1 can...

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Identifiers

PMID: 31641109
DOI: 10.1038/s41419-019-2018-y
PMCID: PMC6805956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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