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Article

Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2009

Yan Tao, Seo Yuji, Kinsella Timothy J

Abstract excerpt

PURPOSE: MLH1 is a key DNA mismatch repair (MMR) protein involved in maintaining genomic stability by participating in the repair of endogenous and exogenous mispairs in the daughter strands during S phase. Exogenous mispairs can result following treatment with several classes of chemotherapeutic drugs, as well as with ionizing radiation. In this study, we investigated the role of the MLH1 protein in determining...

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Source

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Identifiers

PMID: 19861440
DOI: 10.1158/1078-0432.CCR-09-1698
PMCID: PMC2783277

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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