Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2009

Yan Tao, Seo Yuji, Kinsella Timothy J

Abstract excerpt

PURPOSE: MLH1 is a key DNA mismatch repair (MMR) protein involved in maintaining genomic stability by participating in the repair of endogenous and exogenous mispairs in the daughter strands during S phase. Exogenous mispairs can result following treatment with several classes of chemotherapeutic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Antineoplastic Agents
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HCT116 Cells

Share to MutL Protein Homolog 1

Share to Rad51 Recombinase

Share to Radiation, Ionizing

Share to S Phase

Source

Open in PubMed Open full text

Identifiers

PMID: 19861440
DOI: 10.1158/1078-0432.CCR-09-1698
PMCID: PMC2783277

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19861440-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.PMID 19861440Read ↗

MLH1 deficiency enhances radiosensitization with 5-fluorodeoxyuridine by increasing DNA mismatches.Semantic proximity Read ↗

Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis.Semantic proximity Read ↗

Mutations in DNA mismatch repair genes: implications for DNA damage signaling and drug sensitivity (review).Semantic proximity Read ↗

MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinomaSemantic proximity Read ↗

MLH1 deficiency leads to deregulated mitochondrial metabolism.Semantic proximity Read ↗

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes.Semantic proximity Read ↗

Interdependence of DNA mismatch repair proteins MLH1 and MSH2 in apoptosis in human colorectal carcinoma cell linesSemantic proximity Read ↗

Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin.Semantic proximity Read ↗

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.Semantic proximity Read ↗

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.Semantic proximity Read ↗

DNA Mismatch Repair-dependent Response to Fluoropyrimidine-generated DamageSemantic proximity Read ↗

Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.