Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How the Innate Immune DNA Sensing cGAS–STING Pathway Is Involved in Autophagy

8 Dec 2021

Abstract excerpt

The cGAS-STING pathway is a key component of the innate immune system and exerts crucial roles in the detection of cytosolic DNA and invading pathogens. Accumulating evidence suggests that the intrinsic cGAS-STING pathway not only facilitates the production of type I interferons (IFN-I) and inflammatory responses but also triggers autophagy. Autophagy is a homeostatic process that exerts multiple effects on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Immune cells in cancer
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34948027
DOI: 10.3390/ijms222413232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How the Innate Immune DNA Sensing cGAS–STING Pathway Is Involved in AutophagyPMID 34948027Read ↗

The interplay between autophagy and cGAS-STING signaling and its implications for cancerSemantic proximity Read ↗

Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon ProductionSemantic proximity Read ↗

Significance of the cGAS-STING Pathway in Health and DiseaseSemantic proximity Read ↗

The cGAS-STING pathway: a dual regulator of immune response in cancer and therapeutic implicationsSemantic proximity Read ↗

Crosstalk between cGAS-STING pathway and autophagy in cancer immunitySemantic proximity Read ↗

A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse FunctionsSemantic proximity Read ↗

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory ResponseSemantic proximity Read ↗

The cGAS-STING Pathway: A Promising Immunotherapy TargetSemantic proximity Read ↗

Targeting the loss of cGAS / STING signaling in cancerSemantic proximity Read ↗

STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagySemantic proximity Read ↗

cGAS‐STING signaling in cell death: Mechanisms of action and implications in pathologiesSemantic proximity Read ↗

IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.