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Article

Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production

29 Nov 2021

Abstract excerpt

Innate immunity is the front-line defense against infectious microorganisms, including viruses and bacteria. Type I interferons are pleiotropic cytokines that perform antiviral, antiproliferative, and immunomodulatory functions in cells. The cGAS-STING pathway, comprising the main DNA sensor cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS) and stimulator of IFN genes (STING), is a major...

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Immune Response and Inflammation
interferon and immune responses
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34926445
DOI: 10.3389/fcell.2021.748485

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