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Article

STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy

6 Mar 2023

Abstract excerpt

The cGAS-STING pathway plays an important role in host defense by sensing pathogen DNA, inducing type I IFNs, and initiating autophagy. However, the molecular mechanism of autophagosome formation in cGAS-STING pathway-induced autophagy is still unclear. Here, we report that STING directly interacts with WIPI2, which is the key protein for LC3 lipidation in autophagy. Binding to WIPI2 is necessary for...

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PMID: 36872914
DOI: 10.15252/embj.2022112387

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