Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta.

doi:10.1038/s41586-021-04342-0

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Article

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta.

Nature - 1 Feb 2022

Ulrich Lorenz, Halwe Nico Joel, Taddeo Adriano, Ebert Nadine, Schön Jacob, Devisme Christelle, Trüeb Bettina Salome, Hoffmann Bernd, Wider Manon, Fan Xiaoyu, Bekliz Meriem, Essaidi-Laziosi Manel, Schmidt Marie Luisa, Niemeyer Daniela, Corman Victor Max, Kraft Anna, Godel Aurélie, Laloli Laura, Kelly Jenna N, Calderon Brenda M, Breithaupt Angele, Wylezich Claudia, Berenguer Veiga Inês, Gultom Mitra, Osman Sarah, Zhou Bin, Adea Kenneth, Meyer Benjamin, Eberhardt Christiane S, Thomann Lisa, Gsell Monika, Labroussaa Fabien, Jores Jörg, Summerfield Artur, Drosten Christian, Eckerle Isabella Anne, Wentworth David E, Dijkman Ronald, Hoffmann Donata, Thiel Volker, Beer Martin, Benarafa Charaf

Abstract excerpt

Emerging variants of concern (VOCs) are driving the COVID-19 pandemic1,2. Experimental assessments of replication and transmission of major VOCs and progenitors are needed to understand the mechanisms of replication and transmission of VOCs3. Here we show that the spike protein (S) from Alpha (also known as B.1.1.7) and Beta (B.1.351) VOCs had a greater affinity towards the human angiotensin-converting enzyme 2...

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PMID: 34937050
DOI: 10.1038/s41586-021-04342-0
PMCID: PMC8828469

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