Article
The N501Y spike substitution enhances SARS-CoV-2 infection and transmission.
Nature - 1 Feb 2022
Liu Yang, Liu Jianying, Plante Kenneth S, Plante Jessica A, Xie Xuping, Zhang Xianwen, Ku Zhiqiang, An Zhiqiang, Scharton Dionna, Schindewolf Craig, Widen Steven G, Menachery Vineet D, Shi Pei-Yong, Weaver Scott C
Abstract excerpt
The B.1.1.7 variant (also known as Alpha) of SARS-CoV-2, the cause of the COVID-19 pandemic, emerged in the UK in the summer of 2020. The prevalence of this variant increased rapidly owing to an increase in infection and/or transmission efficiency1. The Alpha variant contains 19 nonsynonymous mutations across its viral genome, including 8 substitutions or deletions in the spike protein that interacts with...
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