Article
SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia.
Cell reports - 23 Apr 2024
Meganck Rita M, Edwards Caitlin E, Mallory Michael L, Lee Rhianna E, Dang Hong, Bailey Alexis B, Wykoff Jason A, Gallant Samuel C, Zhu Deanna R, Yount Boyd L, Kato Takafumi, Shaffer Kendall M, Nakano Satoko, Cawley Anne Marie, Sontake Vishwaraj, Wang Jeremy R, Hagan Robert S, Miller Melissa B, Tata Purushothama Rao, Randell Scott H, Tse Longping V, Ehre Camille, Okuda Kenichi, Boucher Richard C, Baric Ralph S
Abstract excerpt
The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the emergence of novel variants of concern (VOCs) that replace ancestral strains. Here, we dissect the complex selective pressures by evaluating variant fitness and adaptation in human respiratory tissues. We evaluate viral properties and host responses to reconstruct forces behind D614G through Omicron (BA.1) emergence. We observe...
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