Article

Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models

2021-06-28

Abstract excerpt

Emerging variants of concern (VOCs) drive the SARS-CoV-2 pandemic. We assessed VOC B.1.1.7, now prevalent in several countries, and VOC B.1.351, representing the greatest threat to populations with immunity to the early SARS-CoV-2 progenitors. B.1.1.7 showed a clear fitness advantage over the progenitor variant (wt-S 614G ) in ferrets and two mouse models, where the substitutions in the spike glycoprotein were ma...

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Literature Corpus work: 74e825eb-d6aa-58f7-935d-91aecb492dc4
DOI: 10.1101/2021.06.28.450190

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