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Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization.

Microbiology spectrum - 29 Jun 2022

Kim Yunjeong, Gaudreault Natasha N, Meekins David A, Perera Krishani D, Bold Dashzeveg, Trujillo Jessie D, Morozov Igor, McDowell Chester D, Chang Kyeong-Ok, Richt Juergen A

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a zoonotic agent capable of infecting humans and a wide range of animal species. Over the duration of the pandemic, mutations in the SARS-CoV-2 spike (S) protein have arisen, culminating in the spread of several variants of concern (VOCs) with various degrees of altered virulence, transmissibility, and neutralizing antibody escape. In this study, we...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35638818
DOI: 10.1128/spectrum.01789-21
PMCID: PMC9241865

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