Article

The SARS-CoV-2 B.1.1.529 Omicron virus causes attenuated infection and disease in mice and hamsters

2021-12-29

Abstract excerpt

<title>Abstract</title> <p>Despite the development and deployment of antibody and vaccine countermeasures, rapidly-spreading SARS-CoV-2 variants with mutations at key antigenic sites in the spike protein jeopardize their efficacy. The recent emergence of B.1.1.529, the Omicron variant1,2, which has more than 30 mutations in the spike protein, has raised concerns for escape from protection by vaccines and therapeu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4753da8d-3e3b-5b0f-af59-8db1202b889a
DOI: 10.21203/rs.3.rs-1211792/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The SARS-CoV-2 B.1.1.529 Omicron virus causes attenuated infection and disease in mice and hamstersDOI 10.21203/rs.3.rs-1211792/v1Read

Characterization of Three Variants of SARS-CoV-2 <i>in vivo</i> Shows Host-Dependent Pathogenicity in HamstersSemantic proximity Read

Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype MiceSemantic proximity Read

Pathogenicity of SARS-CoV-2 Omicron Subvariants JN.1, KP.2, and EG.5.1 in K18-hACE2 Transgenic MiceSemantic proximity Read

Characterization of the SARS-CoV-2 BA.5.5 and BQ.1.1 Omicron Variants in Mice and HamstersSemantic proximity Read

SARS-CoV-2 B.1.351 (beta) variant shows enhanced infectivity in K18-hACE2 transgenic mice and expanded tropism to wildtype mice compared to B.1 variantSemantic proximity Read

Characterization of the SARS-CoV-2 BA.5.5 and BQ.1.1 Omicron variants in mice and hamstersSemantic proximity Read

SARS-CoV-2 Omicron-B.1.1.529 Variant leads to less severe disease than Pango B and Delta variants strains in a mouse model of severe COVID-19Semantic proximity Read

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K VariantsSemantic proximity Read

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron/BA.2Semantic proximity Read

Evolution of Immune Evasion and Host Range Expansion by the SARS-CoV-2 B.1.1.529 (Omicron) VariantSemantic proximity Read

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strainsSemantic proximity Read

SARS-CoV-2 Omicron: Viral Evolution, Immune Evasion, and Alternative Durable Therapeutic Strategies.Semantic proximity Read