Article

Bacterial biodiversity drives the evolution of CRISPR-based phage resistance in <i>Pseudomonas aeruginosa</i>

2019-03-24

Abstract excerpt

Approximately half of all bacterial species encode CRISPR-Cas adaptive immune systems 1 , which provide immunological memory by inserting short DNA sequences from phage and other parasitic DNA elements into CRISPR loci on the host genome 2 . Whereas CRISPR loci evolve rapidly in natural environments 3 , bacterial species typically evolve phage resistance by the mutation or loss of phage receptors under laborato...

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Literature Corpus work: 601b9be9-4096-5873-91bf-a7a849fa3ad2
DOI: 10.1101/586115

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