Article

Phage-mediated resolution of genetic conflict alters the evolutionary trajectory of <i>Pseudomonas aeruginosa</i> lysogens

2023-10-26

Abstract excerpt

The opportunistic human pathogen Pseudomonas aeruginosa is naturally infected by a large class of temperate, transposable, Mu-like phages. We examined the genotypic and phenotypic diversity of P. aeruginosa PA14 populations as they resolve CRISPR autoimmunity, mediated by an imperfect CRISPR match to the Mu-like DMS3 prophage, and show that lysogen evolution is profoundly impacted by CRISPR autoimmunity and phag...

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Literature Corpus work: 30394ee4-fd77-5f87-8b2d-e4728cc8d8ef
DOI: 10.1101/2023.10.24.563318

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