Article
Transient eco-evolutionary dynamics early in a phage epidemic have strong and lasting impact on the long-term evolution of bacterial defences.
PLoS biology - 1 Sept 2023
Watson Bridget Nora Janice, Pursey Elizabeth, Gandon Sylvain, Westra Edze Rients
Abstract excerpt
Organisms have evolved a range of constitutive (always active) and inducible (elicited by parasites) defence mechanisms, but we have limited understanding of what drives the evolution of these orthogonal defence strategies. Bacteria and their phages offer a tractable system to study this: Bacteria can acquire constitutive resistance by mutation of the phage receptor (surface mutation, sm) or induced resistance...
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