Article

Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunity

2021-05-04

Abstract excerpt

Phage therapy can be used in combination with antibiotics to combat infections with bacterial pathogens 1–3 . However, bacteria can rapidly evolve phage resistance via receptor mutation, or using their CRISPR-Cas adaptive immune systems 4 , which insert short phage-derived sequences into CRISPR loci in the bacterial genome 5 to guide sequence-specific cleavage of cognate sequences 6 . Unlike CRISPR-Cas immunit...

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Literature Corpus work: 8e1f7650-8be4-5597-8923-a2a433a29d12
DOI: 10.1101/2021.05.04.442568

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