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Article

The effect of phage genetic diversity on bacterial resistance evolution.

The ISME journal - 1 Mar 2020

Broniewski Jenny M, Meaden Sean, Paterson Steve, Buckling Angus, Westra Edze R

Abstract excerpt

CRISPR-Cas adaptive immune systems are found in bacteria and archaea and provide defence against phage by inserting phage-derived sequences into CRISPR loci on the host genome to provide sequence specific immunological memory against re-infection. Under laboratory conditions the bacterium Pseudomonas aeruginosa readily evolves the high levels of CRISPR-based immunity against clonal populations of its phage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31896785
DOI: 10.1038/s41396-019-0577-7
PMCID: PMC7031251

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