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Mechanisms of Hepatitis B Virus cccDNA and Minichromosome Formation and HBV Gene Transcription

15 Apr 2024

Abstract excerpt

Hepatitis B virus (HBV) is the etiologic agent of chronic hepatitis B, which puts at least 300 million patients at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. HBV is a partially double-stranded DNA virus of the Hepadnaviridae family. While HBV was discovered more than 50 years ago, many aspects of its replicative cycle remain incompletely understood. Central to HBV persistence is the...

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PMID: 38675950
DOI: 10.3390/v16040609

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