Article
The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21.
American journal of respiratory and critical care medicine - 15 Apr 2016
Loss Georg J, Depner Martin, Hose Alexander J, Genuneit Jon, Karvonen Anne M, Hyvärinen Anne, Roduit Caroline, Kabesch Michael, Lauener Roger, Pfefferle Petra Ina, Pekkanen Juha, Dalphin Jean-Charles, Riedler Josef, Braun-Fahrländer Charlotte, von Mutius Erika, Ege Markus J
Abstract excerpt
RATIONALE: Growing up on a farm protects from childhood asthma and early wheeze. Virus-triggered wheeze in infancy predicts asthma in individuals with a genetic asthma risk associated with chromosome 17q21. OBJECTIVES: To test environmental determinants of infections and wheeze in the first year of life, potential modifications of these associations by 17q21, and the implications for different trajectories of...
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