Article
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges.
The Journal of allergy and clinical immunology - 1 Mar 2021
Tang Howard H F, Teo Shu Mei, Sly Peter D, Holt Patrick G, Inouye Michael
Abstract excerpt
In asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition systems; the...
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