Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan.

doi:10.1001/jamanetworkopen.2023.39254

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Article

Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan.

JAMA network open - 1 Nov 2023

Blechter Batel, Chien Li-Hsin, Chen Tzu-Yu, Chang I-Shou, Choudhury Parichoy Pal, Hsiao Chin-Fu, Shu Xiao-Ou, Wong Jason Y Y, Chen Kuan-Yu, Chang Gee-Chen, Tsai Ying-Huang, Su Wu-Chou, Huang Ming-Shyan, Chen Yuh-Min, Chen Chih-Yi, Hung Hsiao-Han, Hu Jia-Wei, Shi Jianxin, Zheng Wei, Rositch Anne F, Chen Chien-Jen, Chatterjee Nilanjan, Yang Pan-Chyr, Rothman Nathaniel, Hsiung Chao Agnes, Lan Qing

Abstract excerpt

Importance: Estimating absolute risk of lung cancer for never-smoking individuals is important to inform lung cancer screening programs. Objectives: To integrate data on environmental tobacco smoke (ETS), a known lung cancer risk factor, with a polygenic risk score (PRS) that captures overall genetic susceptibility, to estimate the absolute risk of lung adenocarcinoma (LUAD) among never-smokers in Taiwan. Design,...

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PMID: 37955902
DOI: 10.1001/jamanetworkopen.2023.39254
PMCID: PMC10644212

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