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Article

Statistical tests for intra-tumour clonal co-occurrence and exclusivity.

PLoS computational biology - 1 Dec 2021

Kuipers Jack, Moore Ariane L, Jahn Katharina, Schraml Peter, Wang Feng, Morita Kiyomi, Futreal P Andrew, Takahashi Koichi, Beisel Christian, Moch Holger, Beerenwinkel Niko

Abstract excerpt

Tumour progression is an evolutionary process in which different clones evolve over time, leading to intra-tumour heterogeneity. Interactions between clones can affect tumour evolution and hence disease progression and treatment outcome. Intra-tumoural pairs of mutations that are overrepresented in a co-occurring or clonally exclusive fashion over a cohort of patient samples may be suggestive of a synergistic...

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Identifiers

PMID: 34910733
DOI: 10.1371/journal.pcbi.1009036
PMCID: PMC8716063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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