Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.

ACS chemical biology - 21 Jan 2022

Yang Yuhong, Xu Yuanyuan, Yue Yuan, Wang Heng, Cui Yumeng, Pan Miaomiao, Zhang Xi, Zhang Lin, Li Haitao, Xu Min, Tang Yefeng, Chen Shawn

Abstract excerpt

Indolmycin (IND) is a microbial natural product that selectively inhibits bacterial tryptophanyl-tRNA synthetase (TrpRS). The tryptophan biosynthesis pathway was recently shown to be an important target for developing new antibacterial agents against Mycobacterium tuberculosis (Mtb). We investigated the antibacterial activity of IND against several mycobacterial model strains. A TrpRS biochemical assay was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Biological Products

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Gene Expression Regulation, Bacterial

Share to Genes, Bacterial

Share to Indoles

Share to Molecular Structure

Share to Mycobacterium bovis

Source

Identifiers

PMID: 34908399
DOI: 10.1021/acschembio.1c00394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents.PMID 34908399Read ↗

In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assemblySemantic proximity Read ↗

Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.Semantic proximity Read ↗

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.Semantic proximity Read ↗

Exploring natural products library to identify potential inhibitors targeting isoniazid-resistant tuberculosis.Semantic proximity Read ↗

Construction of <i>lux</i> -based promoter-reporter platforms in <i>Mycobacterium bovis</i> BCG for screening of drug repurposing small-molecule compounds as new anti-tuberculosis drugsSemantic proximity Read ↗

Structure‐based virtual screening and biological evaluation of novel inhibitors of mycobacterium Z‐ring formationSemantic proximity Read ↗

A chemical-genetic map of the pathways controlling drug potency in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Screening of Compounds for Anti-tuberculosis Activity, and in vitro and in vivo Evaluation of Potential CandidatesSemantic proximity Read ↗

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force DisruptionSemantic proximity Read ↗

Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3.Semantic proximity Read ↗

Pathogen Box screening for hit identification against Mycobacterium abscessusSemantic proximity Read ↗

Identifying a novel mechanism of L-leucine uptake in <i>Mycobacterium tuberculosis</i> using a chemical genomic approachSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.