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Article

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface.

Scientific reports - 25 Aug 2017

Abrahams Katherine A, Cox Jonathan A G, Fütterer Klaus, Rullas Joaquín, Ortega-Muro Fátima, Loman Nicholas J, Moynihan Patrick J, Pérez-Herrán Esther, Jiménez Elena, Esquivias Jorge, Barros David, Ballell Lluís, Alemparte Carlos, Besra Gurdyal S

Abstract excerpt

Drug discovery efforts against the pathogen Mycobacterium tuberculosis (Mtb) have been advanced through phenotypic screens of extensive compound libraries. Such a screen revealed sulfolane 1 and indoline-5-sulfonamides 2 and 3 as potent inhibitors of mycobacterial growth. Optimization in the sulfolane series led to compound 4, which has proven activity in an in vivo murine model of Mtb infection. Here we identify...

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Identifiers

PMID: 28842600
DOI: 10.1038/s41598-017-09642-y
PMCID: PMC5573416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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