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Structure‐based virtual screening and biological evaluation of novel inhibitors of mycobacterium Z‐ring formation

16 Mar 2022

Abstract excerpt

The major part of commercial prodrugs against Mycobacterium tuberculosis (Mtb) demonstrated a significant inhibitory effect on cell division and inhibition of bacterial growth in vitro. However, further implementation often failed to overcome the compensatory system of interchangeable cascades. This is the most common situation for the compounds, which hit the key enzymes activities involved in all basic stages...

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PMID: 35297088
DOI: 10.1002/jcb.30232

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