Article
Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3.
PloS one - 1 Jan 2013
Remuiñán Modesto J, Pérez-Herrán Esther, Rullás Joaquín, Alemparte Carlos, Martínez-Hoyos María, Dow David J, Afari Johnson, Mehta Nalini, Esquivias Jorge, Jiménez Elena, Ortega-Muro Fátima, Fraile-Gabaldón María Teresa, Spivey Vickey L, Loman Nicholas J, Pallen Mark J, Constantinidou Chrystala, Minick Douglas J, Cacho Mónica, Rebollo-López María José, González Carolina, Sousa Verónica, Angulo-Barturen Iñigo, Mendoza-Losana Alfonso, Barros David, Besra Gurdyal S, Ballell Lluís, Cammack Nicholas
Abstract excerpt
Mycobacterium tuberculosis is a major human pathogen and the causative agent for the pulmonary disease, tuberculosis (TB). Current treatment programs to combat TB are under threat due to the emergence of multi-drug and extensively-drug resistant TB. As part of our efforts towards the discovery of new anti-tubercular leads, a number of potent tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide (THPP) and...
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