Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational patterns and their correlation to CHIP-related mutations and age in hematological malignancies.

Blood advances - 9 Nov 2021

Stengel Anna, Baer Constance, Walter Wencke, Meggendorfer Manja, Kern Wolfgang, Haferlach Torsten, Haferlach Claudia

Abstract excerpt

Acquired somatic mutations are crucial for the development of most cancers. We performed a comprehensive comparative analysis of the mutational landscapes and their correlation with CHIP-related (clonal hematopoiesis of indeterminate potential) mutations and patient age of 122 genes in 3096 cases of 28 different hematological malignancies. Differences were observed regarding (1) the median number of mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematologic Neoplasms

Share to Leukemia, Myeloid

Share to Mutation

Share to Myelodysplastic Syndromes

Share to Myeloproliferative Disorders

Share to Splicing Factor U2AF

Source

Open in PubMed Open full text

Identifiers

PMID: 34570179
DOI: 10.1182/bloodadvances.2021004668
PMCID: PMC8579257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational patterns and their correlation to CHIP-related mutations and age in hematological malignancies.PMID 34570179Read ↗

Genomic differences of patients with hematologic malignancies in different age groups.Semantic proximity Read ↗

Molecular Landscape of Therapy-related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast CancersSemantic proximity Read ↗

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions.Semantic proximity Read ↗

Age-related mutations associated with clonal hematopoietic expansion and malignancies.Semantic proximity Read ↗

Clinical, Mutational, and Transcriptomic Characteristics in Elderly Korean Individuals With Clonal Hematopoiesis Driver Mutations.Semantic proximity Read ↗

Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms: A Report of the Association for Molecular Pathology.Semantic proximity Read ↗

The role of clonal progression leading to the development of therapy-related myeloid neoplasms.Semantic proximity Read ↗

Myeloid malignancies: mutations, models and management.Semantic proximity Read ↗

CHIP ahoy: charting a decade of discovery in clonal hematopoiesis.Semantic proximity Read ↗

Ontogeny and Natural History of Therapy-Related Clonal Hematopoiesis From a Multidisciplinary CHIP Clinic.Semantic proximity Read ↗

Age-related mutations and chronic myelomonocytic leukemia.Semantic proximity Read ↗

Landscape of Tumor Suppressor Mutations in Acute Myeloid LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.