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Article

Endothelial Sphingosine-1-Phosphate Receptor 4 Regulates Blood-Brain Barrier Permeability and Promotes a Homeostatic Endothelial Phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Mar 2022

Hansen Lena, Lohfink Niklas, Vutukuri Rajkumar, Kestner Roxane-Isabelle, Trautmann Sandra, Hecht Max, Wagner Pia Viktoria, Spitzer Daniel, Khel Maryam Ibrahim, Macas Jadranka, Ferreirós Nerea, Gurke Robert, Günther Stefan, Pfeilschifter Waltraud, Devraj Kavi

Abstract excerpt

The precise regulation of blood-brain barrier (BBB) permeability for immune cells and blood-borne substances is essential to maintain brain homeostasis. Sphingosine-1-phosphate (S1P), a lipid signaling molecule enriched in plasma, is known to affect BBB permeability. Previous studies focused on endothelial S1P receptors 1 and 2, reporting a barrier-protective effect of S1P1 and a barrier-disruptive effect of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34903569
DOI: 10.1523/JNEUROSCI.0188-21.2021
PMCID: PMC8916766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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